E3 ubiquitin-protein ligase CBLL2

Definition:

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates.

References:

[1]. Yun-Qiang Liu, et al. Human RING finger protein ZNF645 is a novel testis-specific E3 ubiquitin ligase. Asian J Androl. 2010 Sep;12(5):658-66. [Content Brief]

[2]. Manjeet Mukherjee, et al. Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin. EMBO J. 2012 Mar 7;31(5):1308-19. [Content Brief]

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