E3 ubiquitin-protein ligase MARCHF7

Definition:

E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis.

References:

[1]. Guy M Lenk, et al. CRISPR knockout screen implicates three genes in lysosome function. Sci Rep. 2019 Jul 3;9(1):9609. [Content Brief]

[2]. Dennis Flierman, et al. E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11589-94. [Content Brief]

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