E3 ubiquitin-protein ligase RNF167

Definition:

E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway. Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1. Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex. Also involved in protein trafficking and localization. Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2. Does not catalyze ubiquitination of GluA1/GRIA1. Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3. Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B. Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18. Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N.

References:

[1]. Dong Wang, et al. E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression. Mol Cell. 2022 Feb 17;82(4):770-784.e9. [Content Brief]

[2]. H Y Yamada, et al. Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. Oncogene. 2006 Mar 2;25(9):1330-9. [Content Brief]

[3]. Yasuo Yamazaki, et al. Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation. EMBO J. 2013 Feb 20;32(4):524-37. [Content Brief]

[4]. Rakesh Deshar, et al. RNF167 targets Arl8B for degradation to regulate lysosome positioning and endocytic trafficking. FEBS J. 2016 Dec;283(24):4583-4599. [Content Brief]

[5]. Marc P Lussier, et al. Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19426-31. [Content Brief]

[6]. Tingting Li, et al. RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation. Nat Commun. 2021 Feb 16;12(1):1055. [Content Brief]

[7]. Kim Ghilarducci, et al. Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor. FEBS J. 2021 Aug;288(16):4849-4868. [Content Brief]

[8]. Sreeja V Nair, et al. Naturally occurring and tumor-associated variants of RNF167 promote lysosomal exocytosis and plasma membrane resealing. J Cell Sci. 2020 Jun 11;133(11):jcs239335. [Content Brief]

[9]. Jesper R van Dijk, et al. Tumour-associated mutations of PA-TM-RING ubiquitin ligases RNF167/RNF13 identify the PA domain as a determinant for endosomal localization. Biochem J. 2014 Apr 1;459(1):27-36. [Content Brief]

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