E3 ubiquitin-protein ligase RNF38

Definition:

Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.

References:

[1]. Jamie E Sheren, et al. RNF38 encodes a nuclear ubiquitin protein ligase that modifies p53. Biochem Biophys Res Commun. 2013 Nov 1;440(4):473-8. [Content Brief]

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