E3 ubiquitin-protein ligase SH3RF2

Definition:

Has E3 ubiquitin-protein ligase activity. Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation. Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation. Inhibits PPP1CA phosphatase activity.

References:

[1]. Tae Woo Kim, et al. SH3RF2 functions as an oncogene by mediating PAK4 protein stability. Carcinogenesis. 2014 Mar;35(3):624-34. [Content Brief]

[2]. Annick Hendrickx, et al. Docking motif-guided mapping of the interactome of protein phosphatase-1. Chem Biol. 2009 Apr 24;16(4):365-71. [Content Brief]

[3]. Chun-Yu Chen, et al. FLJ23654 encodes a heart protein phosphatase 1-binding protein (Hepp1). Biochem Biophys Res Commun. 2010 Jan 1;391(1):698-702. [Content Brief]

[4]. Michael Wilhelm, et al. Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. J Biol Chem. 2012 Jan 13;287(3):2247-56. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.