E3 ubiquitin-protein ligase TRIM34

Definition:

Functions as antiviral protein and contributes to the defense against retroviral infections. Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses. During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination. In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis. Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis. Promotes also the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells.

References:

[1]. Xing Li, et al. Unique features of TRIM5alpha among closely related human TRIM family members. Virology. 2007 Apr 10;360(2):419-33. [Content Brief]

[2]. Molly Ohainle, et al. TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner. PLoS Pathog. 2020 Apr 13;16(4):e1008507. [Content Brief]

[3]. Xinye An, et al. TRIM34 localizes to the mitochondria and mediates apoptosis through the mitochondrial pathway in HEK293T cells. Heliyon. 2020 Jan 9;6(1):e03115. [Content Brief]

[4]. Dakang Sun, et al. TRIM34 facilitates the formation of multinucleated giant cells by enhancing cell fusion and phagocytosis in epithelial cells. Exp Cell Res. 2019 Nov 1;384(1):111594. [Content Brief]

[5]. Xiaoyan Wang, et al. TRIM34 modulates influenza virus-activated programmed cell death by targeting Z-DNA-binding protein 1 for K63-linked polyubiquitination. J Biol Chem. 2022 Mar;298(3):101611. [Content Brief]

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