E3 ubiquitin-protein ligase TRIM41

Definition:

E3 ligase that plays essential roles in innate antiviral response. Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections. Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS. Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (By similarity). Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response.

References:

[1]. Zhao-Shan Liu, et al. RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses. Cell Biosci. 2018 May 9;8:35. [Content Brief]

[2]. Dan Chen, et al. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. J Biol Chem. 2007 Nov 16;282(46):33776-33787. [Content Brief]

[3]. Girish Patil, et al. TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Influenza A Virus Infection. J Virol. 2018 Jul 31;92(16):e00905-18. [Content Brief]

[4]. Girish Patil, et al. TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Vesicular Stomatitis Virus Infection. Viruses. 2020 Jan 22;12(2):131. [Content Brief]

[5]. Sourav Saha, et al. DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks. Cell Rep. 2020 Dec 29;33(13):108569. [Content Brief]

[6]. Lingyan Wang, et al. Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction. Nat Commun. 2017 Feb 7;8:13876. [Content Brief]

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