E3 ubiquitin-protein ligase TRIM52

Definition:

E3 ubiquitin-protein ligase. Positively regulates the NF-kappa-B signaling pathway.; (Microbial infection) Exhibits antiviral activity against Japanese encephalitis virus (JEV). Ubiquitinates the viral non-structural protein 2 (NS2A) and targets it for proteasome-mediated degradation.

References:

[1]. Wenchun Fan, et al. TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A. Sci Rep. 2016 Sep 26;6:33698. [Content Brief]

[2]. Wenchun Fan, et al. TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway. Mol Immunol. 2017 Feb;82:114-122. [Content Brief]

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