Emerin

Definition:

Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD.

References:

[1]. Cristina Capanni, et al. Emerin-prelamin A interplay in human fibroblasts. Biol Cell. 2009 Sep;101(9):541-54. [Content Brief]

[2]. Jean-Marc Jacque, et al. The inner-nuclear-envelope protein emerin regulates HIV-1 infectivity. Nature. 2006 Jun 1;441(7093):641-5. [Content Brief]

[3]. Yonit Tsatskis, et al. The NEMP family supports metazoan fertility and nuclear envelope stiffness. Sci Adv. 2020 Aug 28;6(35):eabb4591. [Content Brief]

[4]. James M Holaska, et al. Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane. PLoS Biol. 2004 Sep;2(9):E231. [Content Brief]

[5]. Ewa Markiewicz, et al. The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus. EMBO J. 2006 Jul 26;25(14):3275-85. [Content Brief]

[6]. Georgia Salpingidou, et al. A novel role for the nuclear membrane protein emerin in association of the centrosome to the outer nuclear membrane. J Cell Biol. 2007 Sep 10;178(6):897-904. [Content Brief]

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