Enkurin domain-containing protein 1

Definition:

Microtubule-binding protein which regulates microtubule organization and stability. Promotes the stability of astral microtubules and facilitates the proper orientation of the mitotic spindle. This allows the oriented division of basal keratinocytes and contributes to epidermal stratification (By similarity). Required for the assembly of both primary and motile cilia. Destabilizes the interaction between CCP110 and CEP97 by competing with CEP97 for binding to CCP110 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis.

References:

[1]. Ting Song, et al. ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis. EMBO Rep. 2022 May 4;23(5):e54090. [Content Brief]

[2]. Tao Zhong, et al. ENKD1 promotes epidermal stratification by regulating spindle orientation in basal keratinocytes. Cell Death Differ. 2022 Sep;29(9):1719-1729. [Content Brief]

[3]. Fatmanur Tiryaki, et al. ENKD1 is a centrosomal and ciliary microtubule-associated protein important for primary cilium content regulation. FEBS J. 2022 Jul;289(13):3789-3812. [Content Brief]

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