Ephrin type-B receptor 6

Definition:

Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.

References:

[1]. Hiroshi Matsuoka, et al. Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration. J Biol Chem. 2005 Aug 12;280(32):29355-63. [Content Brief]

[2]. Andrew Freywald, et al. The EphB6 receptor inhibits JNK activation in T lymphocytes and modulates T cell receptor-mediated responses. J Biol Chem. 2003 Mar 21;278(12):10150-6. [Content Brief]

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