ER lumen protein-retaining receptor 1

Definition:

Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.

References:

[1]. Irina Raykhel, et al. A molecular specificity code for the three mammalian KDEL receptors. J Cell Biol. 2007 Dec 17;179(6):1193-204. [Content Brief]

[2]. Margarita Cabrera, et al. The retrieval function of the KDEL receptor requires PKA phosphorylation of its C-terminus. Mol Biol Cell. 2003 Oct;14(10):4114-25. [Content Brief]

[3]. Philipp Bräuer, et al. Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor. Science. 2019 Mar 8;363(6431):1103-1107. [Content Brief]

[4]. I Majoul, et al. KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET. Dev Cell. 2001 Jul;1(1):139-53. [Content Brief]

[5]. F M Townsley, et al. Mutational analysis of the human KDEL receptor: distinct structural requirements for Golgi retention, ligand binding and retrograde transport. EMBO J. 1993 Jul;12(7):2821-9. [Content Brief]

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