Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

Definition:

Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity). Stimulates the activity of ETF1 (By similarity). Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes.

References:

[1]. Tianshu Feng, et al. Optimal translational termination requires C4 lysyl hydroxylation of eRF1. Mol Cell. 2014 Feb 20;53(4):645-54. [Content Brief]

[2]. Xinlu Wang, et al. Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed -1 Ribosomal Frameshifting. Cell. 2019 Jan 24;176(3):625-635.e14. [Content Brief]

[3]. S Hoshino, et al. A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells. EMBO J. 1989 Dec 1;8(12):3807-14. [Content Brief]

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