Eukaryotic peptide chain release factor subunit 1

Definition:

Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes.

References:

[1]. Tianshu Feng, et al. Optimal translational termination requires C4 lysyl hydroxylation of eRF1. Mol Cell. 2014 Feb 20;53(4):645-54. [Content Brief]

[2]. L Frolova, et al. A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor. Nature. 1994 Dec 15;372(6507):701-3. [Content Brief]

[3]. Xinlu Wang, et al. Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed -1 Ribosomal Frameshifting. Cell. 2019 Jan 24;176(3):625-635.e14. [Content Brief]

[4]. Akio Yamashita, et al. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev. 2009 May 1;23(9):1091-105. [Content Brief]

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