Eukaryotic translation elongation factor 2 kinase (eEF2K)

Definition:

Eukaryotic elongation factor 2 kinase (eEF2K) is an unusual protein kinase that regulates the elongation stage of protein synthesis by phosphorylating and inhibiting its only known substrate, eEF2. eEF2K is a drug target in cancer, and in cardiovascular and neurodegenerative diseases.

References:

[1]. Liu R, et al. Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases. Acta Pharmacol Sin. 2016 Mar;37(3):285-94. [Content Brief]

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