Fanconi anemia core complex-associated protein 100

Definition:

Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed.

References:

[1]. Chen Ling, et al. FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway. EMBO J. 2007 Apr 18;26(8):2104-14. [Content Brief]

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