Fanconi anemia group D2 protein

Definition:

Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.

References:

[1]. C Timmers, et al. Positional cloning of a novel Fanconi anemia gene, FANCD2. Mol Cell. 2001 Feb;7(2):241-8. [Content Brief]

[2]. I Garcia-Higuera, et al. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol Cell. 2001 Feb;7(2):249-62. [Content Brief]

[3]. Paul R Andreassen, et al. ATR couples FANCD2 monoubiquitination to the DNA-damage response. Genes Dev. 2004 Aug 15;18(16):1958-63. [Content Brief]

[4]. Rocio Montes de Oca, et al. Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin. Blood. 2005 Feb 1;105(3):1003-9. [Content Brief]

[5]. Shobbir Hussain, et al. Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways. Hum Mol Genet. 2004 Jun 15;13(12):1241-8. [Content Brief]

[6]. Anna Motnenko, et al. Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein. PLoS Genet. 2018 Oct 18;14(10):e1007643. [Content Brief]

[7]. Toshiyasu Taniguchi, et al. Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell. 2002 May 17;109(4):459-72. [Content Brief]

[8]. Toshiyasu Taniguchi, et al. S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood. 2002 Oct 1;100(7):2414-20. [Content Brief]

[9]. Koji Nakanishi, et al. Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1110-5. [Content Brief]

[10]. Brian W Freie, et al. A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint. J Biol Chem. 2004 Dec 3;279(49):50986-93. [Content Brief]

[11]. Valeria Naim, et al. The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities. Nat Cell Biol. 2009 Jun;11(6):761-8. [Content Brief]

[12]. Michael Hölzel, et al. FANCD2 protein is expressed in proliferating cells of human tissues that are cancer-prone in Fanconi anaemia. J Pathol. 2003 Oct;201(2):198-203. [Content Brief]

[13]. Niall G Howlett, et al. The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability. Hum Mol Genet. 2005 Mar 1;14(5):693-701. [Content Brief]

[14]. Akihiro Ohashi, et al. Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage. J Biol Chem. 2005 Apr 15;280(15):14877-83. [Content Brief]

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