G-protein coupled receptor 87

Definition:

Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.

References:

[1]. Ken-ichi Tabata, et al. The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2007 Nov 23;363(3):861-6. [Content Brief]

[2]. Yanhong Zhang, et al. The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress. Cancer Res. 2009 Aug 1;69(15):6049-56. [Content Brief]

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