G2/M phase-specific E3 ubiquitin-protein ligase

Definition:

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.

References:

[1]. William S Brooks, et al. G2E3 is a dual function ubiquitin ligase required for early embryonic development. J Biol Chem. 2008 Aug 8;283(32):22304-15. [Content Brief]

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