Gap junction alpha-3 protein

Definition:

Structural component of lens fiber gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells (By similarity). They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.

References:

[1]. Charles K Abrams, et al. Alterations at Arg76 of human connexin 46, a residue associated with cataract formation, cause loss of gap junction formation but preserve hemichannel function. Am J Physiol Cell Physiol. 2018 Nov 1;315(5):C623-C635. [Content Brief]

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