GDP-fucose protein O-fucosyltransferase 2

Definition:

Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (Probable). Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity).

References:

[1]. Lindsay M Ricketts, et al. O-fucosylation is required for ADAMTS13 secretion. J Biol Chem. 2007 Jun 8;282(23):17014-23. [Content Brief]

[2]. J Hofsteenge, et al. C-mannosylation and O-fucosylation of the thrombospondin type 1 module. J Biol Chem. 2001 Mar 2;276(9):6485-98. [Content Brief]

[3]. Chun-I Chen, et al. Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation. EMBO J. 2012 Jul 18;31(14):3183-97. [Content Brief]

[4]. Yi Luo, et al. Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats. J Biol Chem. 2006 Apr 7;281(14):9385-92. [Content Brief]

[5]. Lauren W Wang, et al. O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily. J Biol Chem. 2007 Jun 8;282(23):17024-31. [Content Brief]

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