GPN-loop GTPase 1

Definition:

Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA.

References:

[1]. Diane Forget, et al. The protein interaction network of the human transcription machinery reveals a role for the conserved GTPase RPAP4/GPN1 and microtubule assembly in nuclear import and biogenesis of RNA polymerase II. Mol Cell Proteomics. 2010 Dec;9(12):2827-39. [Content Brief]

[2]. M Nitta, et al. A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA. Nucleic Acids Res. 2000 Nov 1;28(21):4212-8. [Content Brief]

[3]. Clément Carré, et al. Human GTPases associate with RNA polymerase II to mediate its nuclear import. Mol Cell Biol. 2011 Oct;31(19):3953-62. [Content Brief]

[4]. Célia Jeronimo, et al. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Mol Cell. 2007 Jul 20;27(2):262-274. [Content Brief]

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