HCLS1-associated protein X-1

Definition:

Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.

References:

[1]. Ah Young Lee, et al. HS 1-associated protein X-1 is cleaved by caspase-3 during apoptosis. Mol Cells. 2008 Feb 29;25(1):86-90. [Content Brief]

[2]. V Radhika, et al. Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1. J Biol Chem. 2004 Nov 19;279(47):49406-13. [Content Brief]

[3]. Yuchi Han, et al. Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition. Circ Res. 2006 Aug 18;99(4):415-23. [Content Brief]

[4]. Yalan Zhang, et al. Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating. Cell. 2016 Apr 7;165(2):434-448. [Content Brief]

[5]. Elizabeth Vafiadaki, et al. The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival. Mol Biol Cell. 2009 Jan;20(1):306-18. [Content Brief]

[6]. Alan G Ramsay, et al. HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6. Cancer Res. 2007 Jun 1;67(11):5275-84. [Content Brief]

[7]. Y Suzuki, et al. HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases. J Immunol. 1997 Mar 15;158(6):2736-44. [Content Brief]

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