HEAT repeat-containing protein 1

Definition:

Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.

References:

[1]. José-Luis Prieto, et al. Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. Genes Dev. 2007 Aug 15;21(16):2041-54. [Content Brief]

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