Hemogen

Definition:

Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).

References:

[1]. L-L An, et al. High expression of EDAG and its significance in AML. Leukemia. 2005 Aug;19(8):1499-502. [Content Brief]

[2]. Cheng-Chung Liu, et al. Down-regulation of human NDR gene in megakaryocytic differentiation of erythroleukemia K562 cells. J Biomed Sci. 2004 Jan-Feb;11(1):104-16. [Content Brief]

[3]. C Y Li, et al. EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-kappa B. Cell Death Differ. 2004 Dec;11(12):1299-308. [Content Brief]

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