Heterochromatin protein 1-binding protein 3

Definition:

Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal.

References:

[1]. Bamaprasad Dutta, et al. Quantitative profiling of chromatome dynamics reveals a novel role for HP1BP3 in hypoxia-induced oncogenesis. Mol Cell Proteomics. 2014 Dec;13(12):3236-49. [Content Brief]

[2]. Bamaprasad Dutta, et al. Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as a Novel Regulator of Cell Cycle Progression. Mol Cell Proteomics. 2014 Sep;13(9):2183-97. [Content Brief]

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