Histone acetyltransferase type B catalytic subunit

Definition:

Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression. Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks. In addition, acetylates other substrates such as chromatin-related proteins. Acetylates also RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation.; (Microbial infection) Contributes to hepatitis B virus (HBV) replication by acetylating histone H4 at the sites of 'Lys-5' and 'Lys-12' on the covalently closed circular DNA (cccDNA) minichromosome leading to its accumulation within the host cell.

References:

[1]. Eric I Campos, et al. The program for processing newly synthesized histones H3.1 and H4. Nat Struct Mol Biol. 2010 Nov;17(11):1343-51. [Content Brief]

[2]. Joshua J Gruber, et al. HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding. Mol Cell. 2019 Aug 22;75(4):711-724.e5. [Content Brief]

[3]. Paula A Agudelo Garcia, et al. Hat1-Dependent Lysine Acetylation Targets Diverse Cellular Functions. J Proteome Res. 2020 Apr 3;19(4):1663-1673. [Content Brief]

[4]. Yukang Yuan, et al. Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense. Mol Cell. 2020 Feb 20;77(4):734-747.e7. [Content Brief]

[5]. Guang Yang, et al. HAT1 signaling confers to assembly and epigenetic regulation of HBV cccDNA minichromosome. Theranostics. 2019 Sep 25;9(24):7345-7358. [Content Brief]

[6]. Hong Wu, et al. Structural basis for substrate specificity and catalysis of human histone acetyltransferase 1. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8925-30. [Content Brief]

[7]. A M Makowski, et al. Effects of acetylation of histone H4 at lysines 8 and 16 on activity of the Hat1 histone acetyltransferase. J Biol Chem. 2001 Nov 23;276(47):43499-502. [Content Brief]

[8]. Xiaohan Yang, et al. Histone acetyltransferase 1 promotes homologous recombination in DNA repair by facilitating histone turnover. J Biol Chem. 2013 Jun 21;288(25):18271-82. [Content Brief]

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