Homeobox protein CDX-1

Definition:

Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA.

References:

[1]. Ryan W Serra, et al. A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife. 2014 Mar 12;3:e02313. [Content Brief]

[2]. Yimeng Yin, et al. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science. 2017 May 5;356(6337):eaaj2239. [Content Brief]

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