Homeobox protein HMX1

Definition:

DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear.

References:

[1]. B A Amendt, et al. Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site. J Biol Chem. 1999 Apr 23;274(17):11635-42. [Content Brief]

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