Hyaluronan synthase 2

Definition:

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer (Probable). Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (By similarity).

References:

[1]. K Watanabe, et al. Molecular identification of a putative human hyaluronan synthase. J Biol Chem. 1996 Sep 20;271(38):22945-8. [Content Brief]

[2]. Eugenia Karousou, et al. The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination. J Biol Chem. 2010 Jul 30;285(31):23647-54. [Content Brief]

[3]. Kirsi Rilla, et al. Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3. J Biol Chem. 2013 Feb 22;288(8):5973-83. [Content Brief]

[4]. Kosuke Kasai, et al. Phosphorylation of Thr328 in hyaluronan synthase 2 is essential for hyaluronan synthesis. Biochem Biophys Res Commun. 2020 Dec 17;533(4):732-738. [Content Brief]

[5]. R M Melero-Fernandez de Mera, et al. Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2). Matrix Biol. 2019 Jul;80:85-103. [Content Brief]

[6]. Davide Vigetti, et al. Role of UDP-N-acetylglucosamine (GlcNAc) and O-GlcNAcylation of hyaluronan synthase 2 in the control of chondroitin sulfate and hyaluronan synthesis. J Biol Chem. 2012 Oct 12;287(42):35544-35555. [Content Brief]

[7]. Davide Vigetti, et al. Hyaluronan synthesis is inhibited by adenosine monophosphate-activated protein kinase through the regulation of HAS2 activity in human aortic smooth muscle cells. J Biol Chem. 2011 Mar 11;286(10):7917-7924. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.