Immunoglobulin superfamily member 2

Definition:

Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.

References:

[1]. N Meyer, et al. CD4+ CD56+ blastic tumor cells express CD101 molecules. J Invest Dermatol. 2005 Mar;124(3):668-9. [Content Brief]

[2]. M Bagot, et al. CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation. Tissue Antigens. 1997 Nov;50(5):439-48. [Content Brief]

[3]. L R Soares, et al. Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism. J Immunol. 1997 Aug 1;159(3):1115-24. [Content Brief]

[4]. A Bouloc, et al. Triggering CD101 molecule on human cutaneous dendritic cells inhibits T cell proliferation via IL-10 production. Eur J Immunol. 2000 Nov;30(11):3132-9. [Content Brief]

[5]. A Rivas, et al. V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional studies. J Immunol. 1995 May 1;154(9):4423-33. [Content Brief]

[6]. L R Soares, et al. V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation. J Immunol. 1998 Jul 1;161(1):209-17. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.