Interleukin-5 receptor subunit alpha

Definition:

Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts by forming an heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway.

References:

[1]. Seisuke Kusano, et al. Structural basis of interleukin-5 dimer recognition by its α receptor. Protein Sci. 2012 Jun;21(6):850-64. [Content Brief]

[2]. J Tavernier, et al. Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7041-5. [Content Brief]

[3]. J Monahan, et al. Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor. J Immunol. 1997 Oct 15;159(8):4024-34. [Content Brief]

[4]. N Ogata, et al. JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation. Blood. 1998 Apr 1;91(7):2264-71. [Content Brief]

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