Iterative in situ click chemistry (IISCC)

Definition:

Iterative in situ click chemistry (IISCC) is a robust general technology for development of high throughput, inexpensive protein detection agents. In IISCC, the target protein acts as a template and catalyst, and assembles its own ligand from modular blocks of peptides. This process of ligand discovery is iterated to add peptide arms to develop a multivalent ligand with increased affinity and selectivity. The peptide based protein capture agents (PCC) should ideally have the same degree of selectivity and specificity as a monoclonal antibody, along with improved chemical stability.

References:

[1]. Dissertation. Developing Peptide Based Capture Agents for Diagnostics and Therapeutics. Developing Peptide Based Capture Agents for Diagnostics and Therapeutics. 2013.

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