Lysosomal thioesterase PPT2

Definition:

Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.

References:

[1]. B Aguado, et al. Characterization of a human MHC class III region gene product with S-thioesterase activity. Biochem J. 1999 Aug 1;341 ( Pt 3)(Pt 3):679-89. [Content Brief]

[2]. A A Soyombo, et al. Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate specificity. J Biol Chem. 1997 Oct 24;272(43):27456-63. [Content Brief]

[3]. Guillermo Calero, et al. The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2. J Biol Chem. 2003 Sep 26;278(39):37957-64. [Content Brief]

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