Macrophage receptor MARCO

Definition:

Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2.

References:

[1]. O Elomaa, et al. Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region. J Biol Chem. 1998 Feb 20;273(8):4530-8. [Content Brief]

[2]. Liang-Hua Bin, et al. Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair. J Immunol. 2003 Jul 15;171(2):924-30. [Content Brief]

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