Membranoproliferative glomerulonephritis

Definition:

Membranoproliferative glomerulonephritis (MPGN) represents a pattern of glomerular injury, characterized by mesangial proliferation and expansion, lobularization of the glomerular tufts, and double contours. Classification of MPGN has been updated in the 2010s and is now categorized according to the immunofluorescence microscopy findings. MPGN is now recognized as follows: Immunocomplexes-associated MPGN with complement over activation; MPGN with intramembranous dense deposits; and C3 glomerulopathy.

References:

[1]. Jürgen Floege, et al. Primary glomerulonephritides. Lancet. 2016 May 14;387(10032):2036-48. [Content Brief]

[2]. Maurizio Salvadori, et al. Reclassification of membranoproliferative glomerulonephritis: Identification of a new GN: C3GN. World J Nephrol. 2016 Jul 6;5(4):308-20. [Content Brief]

[3]. Sophia Lionaki, et al. Understanding the complement-mediated glomerular diseases: focus on membranoproliferative glomerulonephritis and C3 glomerulopathies. APMIS. 2016 Sep;124(9):725-35. [Content Brief]

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