Motile sperm domain-containing protein 2

Definition:

Endoplasmic reticulum-anchored receptor which modulates interorganelle contacts by interacting with other organelle-bound proteins via their FFAT motif. Might have a more important role in endoplasmic reticulum and endosomes contacts. Promotes migration of primary monocytes and neutrophils, in response to various chemokines.

References:

[1]. Thomas Di Mattia, et al. Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites. EMBO Rep. 2018 Jul;19(7):e45453. [Content Brief]

[2]. Itzhak Mendel, et al. Identification of Motile Sperm Domain-Containing Protein 2 as Regulator of Human Monocyte Migration. J Immunol. 2017 Mar 1;198(5):2125-2132. [Content Brief]

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