mRNA export factor GLE1

Definition:

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).

References:

[1]. Frederic Kendirgi, et al. An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export. J Cell Biol. 2003 Mar 31;160(7):1029-40. [Content Brief]

[2]. J L Watkins, et al. The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6779-84. [Content Brief]

[3]. Frederic Kendirgi, et al. Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA. Mol Biol Cell. 2005 Sep;16(9):4304-15. [Content Brief]

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