Mucolipin-2

Definition:

Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway. May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events.

References:

[1]. Cyntia Curcio-Morelli, et al. Functional multimerization of mucolipin channel proteins. J Cell Physiol. 2010 Feb;222(2):328-35. [Content Brief]

[2]. Shaya Lev, et al. Constitutive activity of the human TRPML2 channel induces cell degeneration. J Biol Chem. 2010 Jan 22;285(4):2771-82. [Content Brief]

[3]. Claudia Karacsonyi, et al. Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs. Traffic. 2007 Oct;8(10):1404-14. [Content Brief]

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