Myotubularin-related protein 3

Definition:

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues.

References:

[1]. R Zhao, et al. FYVE-DSP1, a dual-specificity protein phosphatase containing an FYVE domain. Biochem Biophys Res Commun. 2000 Apr 2;270(1):222-9. [Content Brief]

[2]. D M Walker, et al. Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity. Curr Biol. 2001 Oct 16;11(20):1600-5. [Content Brief]

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