NLR family CARD domain-containing protein 4

Definition:

Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).

References:

[1]. Jason S Damiano, et al. Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem J. 2004 Jul 1;381(Pt 1):213-9. [Content Brief]

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