Nuclear valosin-containing protein-like

Definition:

Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity.

References:

[1]. Joonyoung Her, et al. The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly. Biochem Biophys Res Commun. 2012 Jan 20;417(3):1086-92. [Content Brief]

[2]. Nobuhiro Hiraishi, et al. AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74. Biochem Biophys Res Commun. 2015 Nov 20;467(3):534-40. [Content Brief]

[3]. Masami Nagahama, et al. NVL2 is a nucleolar AAA-ATPase that interacts with ribosomal protein L5 through its nucleolar localization sequence. Mol Biol Cell. 2004 Dec;15(12):5712-23. [Content Brief]

[4]. Yuki Yoshikatsu, et al. NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing. Biochem Biophys Res Commun. 2015 Aug 28;464(3):780-6. [Content Brief]

[5]. Yu-Hua Lo, et al. Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1/WDR74 Important for Localization and Interaction with Rix7/NVL2. Structure. 2017 May 2;25(5):762-772.e4. [Content Brief]

[6]. Masami Nagahama, et al. The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1. Biochem Biophys Res Commun. 2006 Aug 4;346(3):1075-82. [Content Brief]

[7]. Nobuhiro Hiraishi, et al. WDR74 participates in an early cleavage of the pre-rRNA processing pathway in cooperation with the nucleolar AAA-ATPase NVL2. Biochem Biophys Res Commun. 2018 Jan 1;495(1):116-123. [Content Brief]

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