P antigen family member 4

Definition:

Intrinsically disordered protein that potentiates the transcriptional activator activity of JUN. Protects cells from stress-induced apoptosis by inhibiting reactive oxygen species (ROS) production and via regulation of the MAPK signaling pathway.

References:

[1]. Yu Zeng, et al. The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein. J Biol Chem. 2011 Apr 22;286(16):13985-94. [Content Brief]

[2]. Chengcheng Lv, et al. PAGE4 promotes prostate cancer cells survive under oxidative stress through modulating MAPK/JNK/ERK pathway. J Exp Clin Cancer Res. 2019 Jan 18;38(1):24. [Content Brief]

[3]. Krithika Rajagopalan, et al. The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation. Biochim Biophys Acta. 2014 Feb;1842(2):154-63. [Content Brief]

[4]. Yu Zeng, et al. Prostate-associated gene 4 (PAGE4) protects cells against stress by elevating p21 and suppressing reactive oxygen species production. Am J Clin Exp Urol. 2013 Dec 25;1(1):39-52. [Content Brief]

[5]. Prakash Kulkarni, et al. Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2644-E2653. [Content Brief]

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