Palmitoyltransferase ZDHHC17

Definition:

Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3. Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade (By similarity). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May play a role in Mg(2+) transport. Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Palmitoylates CASP6, thereby preventing its dimerization and subsequent activation.

References:

[1]. Niels H Skotte, et al. Palmitoylation of caspase-6 by HIP14 regulates its activation. Cell Death Differ. 2017 Mar;24(3):433-444. [Content Brief]

[2]. Jixin Ding, et al. ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization. Mol Cell Biol. 2009 Mar;29(6):1459-71. [Content Brief]

[3]. Charles E Ducker, et al. Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase. Oncogene. 2004 Dec 9;23(57):9230-7. [Content Brief]

[4]. Raffaello Verardi, et al. Structural Basis for Substrate Recognition by the Ankyrin Repeat Domain of Human DHHC17 Palmitoyltransferase. Structure. 2017 Sep 5;25(9):1337-1347.e6. [Content Brief]

[5]. Roshni R Singaraja, et al. HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. Hum Mol Genet. 2002 Nov 1;11(23):2815-28. [Content Brief]

[6]. Angela Goytain, et al. Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport. J Biol Chem. 2008 Nov 28;283(48):33365-74. [Content Brief]

[7]. Kun Huang, et al. Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins. Neuron. 2004 Dec 16;44(6):977-86. [Content Brief]

[8]. Stefanie L Butland, et al. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. Hum Mol Genet. 2014 Aug 1;23(15):4142-60. [Content Brief]

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