PAT complex subunit CCDC47

Definition:

Component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. WDR83OS/Asterix is the substrate-interacting subunit of the PAT complex, whereas CCDC47 is required to maintain the stability of WDR83OS/Asterix. The PAT complex favors the binding to TMDs with exposed hydrophilic amino acids within the lipid bilayer and provides a membrane-embedded partially hydrophilic environment in which the first transmembrane domain binds. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Involved in the regulation of calcium ion homeostasis in the ER. Required for proper protein degradation via the ERAD (ER-associated degradation) pathway. Has an essential role in the maintenance of ER organization during embryogenesis (By similarity).

References:

[1]. Philip T McGilvray, et al. An ER translocon for multi-pass membrane protein biogenesis. Elife. 2020 Aug 21;9:e56889. [Content Brief]

[2]. Patrick J Chitwood, et al. An intramembrane chaperone complex facilitates membrane protein biogenesis. Nature. 2020 Aug;584(7822):630-634. [Content Brief]

[3]. Shinichiro Yamamoto, et al. Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity. Dev Biol. 2014 Sep 1;393(1):33-43. [Content Brief]

[4]. Marie Morimoto, et al. Bi-allelic CCDC47 Variants Cause a Disorder Characterized by Woolly Hair, Liver Dysfunction, Dysmorphic Features, and Global Developmental Delay. Am J Hum Genet. 2018 Nov 1;103(5):794-807. [Content Brief]

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