Peptidyl-prolyl cis-trans isomerase D

Definition:

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines.; (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release.

References:

[1]. J D Leverson, et al. Point mutations in v-Myb disrupt a cyclophilin-catalyzed negative regulatory mechanism. Mol Cell. 1998 Jan;1(2):203-11. [Content Brief]

[2]. Tony C Luu, et al. Cyclophilin-40 has a cellular role in the aryl hydrocarbon receptor signaling. FEBS Lett. 2008 Sep 22;582(21-22):3167-73. [Content Brief]

[3]. Leah J Anderson, et al. Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion. Virol J. 2011 Jun 28;8:329. [Content Brief]

[4]. L Alex Gaither, et al. Multiple cyclophilins involved in different cellular pathways mediate HCV replication. Virology. 2010 Feb 5;397(1):43-55. [Content Brief]

[5]. Jana Jandova, et al. Cyclophilin 40 alters UVA-induced apoptosis and mitochondrial ROS generation in keratinocytes. Exp Cell Res. 2013 Mar 10;319(5):750-60. [Content Brief]

[6]. Tara L Davis, et al. Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. PLoS Biol. 2010 Jul 27;8(7):e1000439. [Content Brief]

[7]. F Pirkl, et al. Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40. J Mol Biol. 2001 May 11;308(4):795-806. [Content Brief]

[8]. Joel D Pearson, et al. The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein. BMC Cancer. 2012 Jun 8;12:229. [Content Brief]

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