Pericentrin

Definition:

Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome.

References:

[1]. Q Li, et al. Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1. J Cell Sci. 2001 Feb;114(Pt 4):797-809. [Content Brief]

[2]. Shoko Shimizu, et al. DISC1-kendrin interaction is involved in centrosomal microtubule network formation. Biochem Biophys Res Commun. 2008 Dec 26;377(4):1051-6. [Content Brief]

[3]. M R Flory, et al. Identification of a human centrosomal calmodulin-binding protein that shares homology with pericentrin. Proc Natl Acad Sci U S A. 2000 May 23;97(11):5919-23. [Content Brief]

[4]. Kazuhiko Matsuo, et al. Involvement of a centrosomal protein kendrin in the maintenance of centrosome cohesion by modulating Nek2A kinase activity. Biochem Biophys Res Commun. 2010 Jul 23;398(2):217-23. [Content Brief]

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