Periodic paralysis

Definition:

The periodic paralyses are characterized by episodic muscle weakness often related to potassium levels. They include hyperkalaemic periodic paralysis (HyperPP), hypokalaemic periodic paralysis (HypoPP), and Andersen-Tawil syndrome (ATS) caused by mutations in genes encoding for subunits of channel proteins of the skeletal muscle membrane.

References:

[1]. Dipa L Raja Rayan, et al. Skeletal muscle channelopathies: nondystrophic myotonias and periodic paralysis. Curr Opin Neurol. 2010 Oct;23(5):466-76. [Content Brief]

[2]. J Finsterer, et al. Primary periodic paralyses. Acta Neurol Scand. 2008 Mar;117(3):145-58. [Content Brief]

[3]. S L Venance, et al. The primary periodic paralyses: diagnosis, pathogenesis and treatment. Brain. 2006 Jan;129(Pt 1):8-17. [Content Brief]

[4]. V Sansone, et al. Treatment for periodic paralysis. Cochrane Database Syst Rev. 2008 Jan 23;(1):CD005045. [Content Brief]

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