Peripheral T cell lymphoma

Definition:

Peripheral T cell lymphomas (PTCLs) are a group of rare lymphomas originating from mature (i.e., post-thymic or "peripheral") T lymphocytes and NK cells. With regard to the current WHO classification, leukemic, cutaneous, nodal, and extranodal PTCL are distinguished. The most common subtypes worldwide are the nodal T cell lymphomas. In the nodal T cell lymphomas, the major subtypes are PTCL, not otherwise specified (PTCL-NOS), angioimmunoblastic T cell lymphoma (AITL), anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) and ALK-negative ALCL. Novel approaches are gradually clarifying the molecular pathogenesis of PTCLs. ALK gene translocation and dual specificity phosphatase 22 (DUSP22) gene translocation are seen in ALK-positive ALCL and ALK-negative ALCL, respectively. Recently, gene mutations in epigenetic regulators, including Ten-Eleven Translocation 2 (TET2), DNA methyltransferase 3A (DNMT3A), and isocitrate dehydrogenase 1 /2 (IDH1/2), are discovered in hematologic malignancies. The mutation frequencies were especially high in AITL and PTCL-NOS.

References:

[1]. Alessandro Broccoli, et al. Peripheral T-cell lymphoma, not otherwise specified. Blood. 2017 Mar 2;129(9):1103-1112. [Content Brief]

[2]. Mamiko Sakata-Yanagimoto, et al. Molecular Pathogenesis of Peripheral T Cell Lymphoma. Curr Hematol Malig Rep. 2015 Dec;10(4):429-37. [Content Brief]

[3]. Mamiko Sakata-Yanagimoto, et al. Multistep tumorigenesis in peripheral T cell lymphoma. Int J Hematol. 2015 Nov;102(5):523-7. [Content Brief]

[4]. Peter Reimer, et al. New developments in the treatment of peripheral T-cell lymphoma - role of Belinostat. Cancer Manag Res. 2015 Jun 3;7:145-51. [Content Brief]

[5]. Rosalind F Sandell, et al. Genetic Landscape and Classification of Peripheral T Cell Lymphomas. Curr Oncol Rep. 2017 Apr;19(4):28. [Content Brief]

[6]. Tatyana Feldman, et al. Treatment of Peripheral T-Cell Lymphoma in Community Settings. Clin Lymphoma Myeloma Leuk. 2017 Jun;17(6):354-361. [Content Brief]

[7]. Yaping Zhang, et al. Therapeutic options in peripheral T cell lymphoma. J Hematol Oncol. 2016 Apr 12;9:37. [Content Brief]

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