Periphilin-1

Definition:

Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin. Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation.

References:

[1]. Yiping Zhu, et al. NP220 mediates silencing of unintegrated retroviral DNA. Nature. 2018 Dec;564(7735):278-282. [Content Brief]

[2]. Megumi Kurita, et al. CR/periphilin is a transcriptional co-repressor involved in cell cycle progression. Biochem Biophys Res Commun. 2007 Dec 28;364(4):930-6. [Content Brief]

[3]. Megumi Kurita, et al. Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest. Biochem Biophys Res Commun. 2004 Nov 12;324(2):554-61. [Content Brief]

[4]. Iva A Tchasovnikarova, et al. GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells. Science. 2015 Jun 26;348(6242):1481-1485. [Content Brief]

[5]. Shideh Kazerounian, et al. Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope. J Biol Chem. 2003 Sep 19;278(38):36707-17. [Content Brief]

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